Validity of DSM-5 dementia criteria for population research in India.

characteristics of the sample and methodology are published elsewhere [7]. Our database comprised 1,005 individuals above the age of 65 who were interviewed from a predefined catchment population in Chennai, India. This corresponded to a response rate of 72% [3]. The calculations for sample size [7] , the detailed report of the survey, and the characteristics of the catchment population are described elsewhere [3]. Four cases were excluded from the analyses due to the lack of sufficient information to classify the participants according to DSM-5. The same variables that were used for developing the DSM-IV dementia algorithm, were also used to create the DSM-5 criteria to detect mild and major NCD: a) criterion A1 and criterion B were defined as RELSCORE ≥ 0.5; b) criterion A2 was defined as COGSCORE less than 1.5 standard deviations from the mean for major NCD, and less than 1.0 standard deviations from the mean for mild NCD (stratified by age and education), and c) criteria C and D were the same as those used in the DSM-IV dementia algorithm reported earlier [8]. The prevalence of DSM-5 NCD among older people aged over 65 was (4.2%), six times greater than the DSM-IV dementia prevalence (0.8%); however, it was considerably lower than the 10/66 survey dementia diagnosis (9%). The reliability between DSM-5 major NCD compared with 10/66 dementia diagnosis was moderate (k = 0.52, p < 0.001) (table 1). Although, the specificity of DSM-5 major NCD was high (98.9%), the sensitivity of the criteria was low (42.7%). When mild and major NCD were combined in a single matrix, there was an improvement in sensitivity of combined NCD (61.3%). In conclusion, the validity of DSM-5 in Indian population is not robust, although detection of dementia cases is much better compared to DSM-IV. Future DSM revisions should consider modification of the criteria to one that is culturally sensitive and appropriate even to low-and middle-income countries, particularly functional decline owing to cognitive decline. Including both major and mild neurocognitive disorders in community screening might give a better yield than using only major NCD. Most population-based studies from India have reported a low prevalence of dementia compared to American or European studies [1]. A speculation on this discrepancy impugned the validity of dementia diagnostic criteria (DSM-III and IV) in the Indian population [2]. Subsequently, a study investigating the validity of de-mentia diagnosis in the south Indian urban population reported poor …